Early detection of shock allows for earlier intervention, which reduces morbidity and saves lives. Furthermore, the ability to monitor cellular perfusion enables physicians to observe the patient’s response to clinical intervention, such as blood transfusion or drug therapy. The CellSat™ cellular oximeter technology allows for an unprecedented view into a patient's cellular metabolism to determine when the patient’s oxygenation status has been restored.
Rendering of proposed CellSat™ 100 for the ICU
Prototype of Optic Hand Pad™
Rendering of proposed CellSat™ 100 for emergency responders
Principle of operation:
The CellSat system uses the measurement of cellular oxygenation in the first digital interosseous muscle (back of the hand) as a surrogate to peripheral tissue perfusion. The device shines light in the visible and near-infrared regions (500-800 nm) onto the surface of the skin and it measures the reflected light that returns to the surface. Our patented pattern-matching algorithm analyzes the optical spectra to produce real-time cellular oxygenation measurements from the muscle.
What it does:
During shock, microcirculatory derangement will occur that results in poor tissue perfusion. With inadequate perfusion, cellular oxygenation will drop quickly.
There are several causes for shock, and the CellSat technology will be able to identify shock, no matter what the cause. For example, in acute hemorrhage, red cells may be fully oxygenated but total blood volume is too low. This would lead to vasoconstriction in muscle and low CellSat readings. In cardiopulmonary failure, either the heart or lungs, or both, have a problem that would result in low levels of oxygen in arterial blood. Patients with anemia may have red cells that are fully oxygenated, but there are too few of them to deliver enough oxygen to tissues.
In the plot below, the CellSat device was able to continuously monitor cellular oxygenation in a trauma patient during treatment. After two fluid boluses, CellSat values were stabilized. Pulse oximetry did not change during this period – it is not responsive to shock.
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