Direct Cellular Oximetry for Monitoring Patient Health

CellSat™ Technology

“This new medical instrument (CellSat™) has the potential for detecting mild to moderate shock during the "Golden Hour" when the clinician still has the opportunity to reverse potentially fatal deterioration with current therapies.”

- Robert D. Guthrie, MD, System Chair of Pediatrics (retired), Allegheny Health Network

The “Holy Grail” of oximetry for critical care is to directly measure oxygen where it is actually used – inside the cells. Only the new Opticyte CellSat™ technology can make this measurement. This new device will enable clinicians to monitor and better maintain sufficient oxygen levels in the body’s tissues and organs, helping to prevent multiple organ failure, loss of limbs, or death.

 

Early detection of shock allows for earlier intervention, which reduces morbidity and saves lives. Furthermore, the ability to monitor cellular perfusion enables physicians to observe the patient’s response to clinical intervention, such as fluid replacement, blood transfusion or drug therapy. The CellSat™ cellular oximeter technology allows for an unprecedented view into a patient's cellular metabolism to determine when the patient’s oxygenation status has been restored.

 

Rendering of CellSat™ Device for the ICU

 

 

 

 

 

 

 

 

 

 

 

 

 

Prototype of Optic Hand Pad™

 

 

 

 

 

 

 

 

 

 

 

 

Rendering of CellSat™ Device for Emergency Responders

 

 

 

 

 

 

 

 

 

 

 

How Does the CellSat™ Technology Work?

Low oxygenation in peripheral tissue such as muscle may serve as an early warning of insufficient circulating oxygen in the body. During shock, blood flow is diverted to the core (brain, heart, and kidneys) at the expense of skin and muscle. Low cellular oxygenation in muscle is the “canary in the coal mine” for impending shock.

 

The CellSat™ technology uses the measurement of cellular oxygenation in the first digital interosseous muscle (back of the hand) as a surrogate for peripheral tissue perfusion. The device shines light in the visible and near-infrared regions (500-800 nm) onto the surface of the skin and it measures the reflected light that returns to the surface. A proprietary pattern-matching algorithm analyzes optical spectra to produce real-time cellular oxygenation measurements from muscle.

 

How is CellSat™ Technology Different from other Oximeters?

Currently available tissue oximeters use wavelengths in the near-infrared region to measure blood oxygenation in peripheral muscle. Due to the fact that blood from arterial, capillary, and venous compartments all contribute to the tissue oxygenation measurement, these current devices have difficulty obtaining clear results that reflect oxygenation inside cells.

 

Opticyte technology is novel in that we use a broad spectrum of both visible and near-infrared light to separately measure oxygenation inside cells and in the blood, providing a more accurate reading of patient health.

 

 

Pulse oximeters are commonly used in emergency departments (EDs), operation rooms (ORs) and intensive care units (ICUs) to monitor arterial blood oxygen levels.  While pulse oximeters provide excellent value by measuring circulating oxygen and pulse rate, they do not indicate shock.

 

The CellSat™ device is being developed to measure oxygenation inside cells, where oxygen is needed and used.  With a precise measurement of the amount of oxygen getting to the cells, clinicians will be able to make optimal decisions to restore and maintain adequate oxygen levels in the body.

 

Opticyte, Inc.

University of Washington

Box 352141

4000 Mason Road, Suite 300

Seattle, WA 98195