Opticyte is focused on delivering a real-time cellular oximeter that will take the guesswork out of knowing patient oxygen status and response to treatment.
One of the primary goals of clinicians caring for critically ill patients is to restore and maintain sufficient oxygen levels in the body’s tissues and organs. Prolonged periods of low tissue and organ oxygen levels lead to clinical shock, resulting in multiple organ failure, loss of limbs and death.
Current measurement methods are too slow or rely on indirect clinical information, leaving clinicians guessing at patient condition, treatment protocol, and treatment effectiveness. Clinicians need a device that provides direct monitoring of cellular oxygenation to provide real-time information on patient condition and treatment effectiveness. This will allow clinicians in intensive care, surgery, and emergency medicine to diagnose and monitor many challenging conditions, most notably:
Of all these conditions, septic shock represents the most significant clinical need and opportunity for the Opticyte cellular oximetry technology.
What is Septic Shock?
Shock is a life-threatening condition that occurs when the body is not getting enough blood flow. As a result, cells and organs do not receive enough oxygen and nutrients to function properly.
In a healthy body, cells are perfused with blood being routed through the local capillary beds. The capillary blood delivers oxygen and nutrients to cells and carries away cellular waste products. During septic shock, capillary bed blood flow is disrupted by the presence of infection. Septic shock is a serious condition, defined by the body’s inability to respond to fluid replacement. If this condition persists, cells begin to die from lack of oxygen – ultimately leading to organ failure or death.
Sepsis represents one of the most challenging issues facing the U.S. healthcare system today:
How is Shock Measured Today?
There are several methods currently used for indirectly estimating oxygen levels in tissues and organs when clinical shock is suspected.
How Does the Opticyte Cellular Oximeter Compare to a Pulse Oximeter?
Whereas pulse oximetry readings provide information about the oxygen supply in arterial blood, our novel Opticyte technology directly measures oxygen in the cells, where it is needed and used.
In a trauma patient admitted to the emergency department, Opticyte’s CellSat™ technology continuously monitored cellular oxygenation. When cellular oxygen levels dipped to dangerous levels, pulse oximetry showed no warning signs. After administering two fluid boluses, cellular oxygen levels were stabilized.
Pulse oximetry readings may appear unchanged while cellular oxygen levels are headed in a dangerous downward trend.
Direct monitoring of cellular oxygen clearly represents the “Holy Grail” of effective shock detection and treatment. Opticyte’s novel technology will soon allow clinicians an unprecedented view into the oxygenation status of their critically ill patients.